Gerald Gus Sisco was born on September 19, 1946, He attended South High School and Bakersfield College. He then entered into active duty with the U.S. Navy during the Vietnam War. Upon completion of Navy duty, Gus attended the University of California at Northridge, where he earned a Master of Fine Arts degree at the San Francisco Institute of Fine Arts. Gerald lived most of his life in San Francisco and was represented by the Lawson de Celle Gallery there.

Gerald Sisco was an expert printer who represented the philosophies and practices of the 1970s American Minimalist movement. While in San Francisco Gerald Sisco worked for Crown Point Press, printing the work of many prominent artists which included that of Sol Lewitt.